Topic “a45”
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2008-05-22
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Prognosis of women with stage IV breast cancer depends on detection of circulating tumor cells rather than disseminated tumor cells
[…] DTC detection in the BM of metastatic breast cancer patients. Materials and methods: BM aspirates from 138 patients were screened for DTC with the pancytokeratin mAb A45-B/B3, according to the ISHAGE classification. One hundred and ten patients (80%) were enrolled before first-line treatment. Thirty-seven patients were simultaneously screened for CTC in the blood. Results: DTC detection rate in the BM was 59%. DTC were associated with bone metastasis (P = 0.0001), but not with a poorer overall […] read